This sugar plays a vital role in stimulating the immune system. The sugar needs to be extracted and stabilized properly for efficacy. It is usually harvested from the aloe vera plant. There are over 240 species of aloe but the Aloe Barbadensis Miller variety is the most nutrient dense. It grows very well in volcanic soil. Aloe has been mentioned in literature for over 5,000 years as having healing and curative properties. No one understood what made aloe vera work. It turned out to be something no one was paying attention to—it was the sugar. No one was thinking sugar could have any affect for good on immune systems. But aloe vera was densely enriched with the sugar mannose. Mannose gave aloe its immune stimulating qualities. Aloe vera has been put into lots of different types of products like lotions and shampoos. It’s also easy to buy a jug of aloe vera juice but all of these things produce little or no benefit. Why is that?

The stalk of the aloe plant when broken off has a gel like substance which contains the mannose molecules. Aloe users know they cannot reuse the same stalk over and over. They have to break off a new stalk if they want it to work. This is because the active component in aloe, mannose, is a labile molecule. This means a few hours after harvesting and being exposed to oxygen, the sugar is completely destroyed by enzymes. This is the reason it is imperative the mannose be extracted from the aloe and stabilized properly. Most manufacturers of aloe know nothing about stabilizing mannose. So, while breaking a fresh stalk of the plant worked, most aloe products don’t! For those who know where to get what is efficacious, the benefits are unparalleled.

The inner gel of the plant consists of acemannan. Acemannan is virtually all beta (1,4) linked mannose molecules. There are numerous scientific studies demonstrating that these mannose molecules induce fibroblast proliferation. Fibroblasts are the cells that produce collagen which is the most common protein in the body. Acemannan stimulates the fibroblasts to produce collagen and growth factors involved in healing the skin and connective tissue in the body. Acemannan exerts these effects via the AKT/mTOR mediated protein translation mechanism signaling pathway. Acemannan was found to significantly accelerate wound closure and cell reproduction. It represents an effective, alternative therapy for skin surface wounds. During World War II atomic bomb testing at Los Alamos, it was found to be extremely beneficial in treating radiation burns caused by nuclear explosions.

Mannose is incorporated into glycoprotein receptors on cell surfaces. It modulates the immune system primarily by activating macrophages. The immune system cells are primed to look for mannose as it is the terminal sugar on many microbes and invaders. Macrophages phagocytize (eat) bacteria and cellular debris associated with tissue inflammation. Elevated white blood cell counts can indicate ongoing disease processes. But what we really want is an actively engaged immune system—not a sluggish one. Mannose is like the gasoline in the gas tank of the macrophage. You don’t want to run out of gas!

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